Beijing, August 28, 2025, 05:11 PM PKT – Chinese scientists are poised for additional pig-to-human lung xenotransplant trials. This follows the first successful genetically modified pig lung transplant into a brain-dead patient, as reported by Nature Medicine.
Breakthroughs in Xenotransplantation
May 2024 saw a groundbreaking procedure that marked a significant leap in xenotransplantation research. The transplanted pig lung functioned for nine days in the recipient. Professor He Jianxing, the lead researcher at Guangzhou Medical University, highlighted the focus on refining outcomes, saying, “We aim to refine genetic edits for safer clinical trials.”
Leveraging CRISPR Technology
The historic transplant utilized a Bama pig with six CRISPR edits aimed at reducing immune rejection. However, several significant challenges were faced by the medical team.
Key Challenges Encountered
- Fluid buildup in the transplanted organ
- Managing immune responses
- Concerns about long-term organ functionality
Researchers are addressing these issues before proceeding to the next trial phase. Trials with living patients are anticipated by 2026.
Tackling Global Organ Shortage
This initiative seeks to address the pressing global shortage of donor organs. In 2024, only 8,236 lung transplants were conducted worldwide, insufficient to meet the demand. Clonorgan Biotechnology plans to provide genetically modified pigs with advanced edits to further lower rejection risks.
A health official involved with the project remarked, “This is a game-changer.”
Stay updated at nenagency.
